ETIOPATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA
Abstract
The development of BPD is facilitated by many factors: immaturity of lung tissue, deficiency of surfactant, exposure to oxygen in high concentrations during mechanical ventilation. High oxygen concentrations have a damaging effect on both the structural and functional state of lung cells. Molecules of reactive oxygen radicals and peroxide compounds that destroy surfactant have an aggressive damaging effect. The damaging effect is associated not only with exposure to reactive oxygen radicals, but also with a decrease in the activity of antioxidant activity, a pronounced decrease in protective functions from the effects of peroxide agents in very premature babies. Barotrauma of the lungs plays a major role in the formation of BPD.
Downloads
References
Bronchopulmonary dysplasia: Guidelines / Ed. N.N. Volodin. – Moscow: Medical University, 2010. – 56 p.
Davydov I.V., Yatsyk G.V., Lukina O.F., et al. Experience with inhaled steroids in children with bronchopulmonary dysplasia in the first six months of life // Pediatricheskaja farmakologija. – 2008. – №6. – P.42-44.
Ilyina S.V., Namazova-Baranova L.S., Baranov A.A. Vaccination for All: tough answers to difficult questions: a guide for physicians. – Moscow: Pediatr, 2016. – 204 p.
The national program to optimize feeding children first year of life in the Russian Federation. – Moscow, 2010. – 86 p.
Ovsyannikov D.Yu., Bolibok A.M., Daniel M. Abu-Modern approaches to prevention and treatment of bronchopulmonary dysplasia // Vestnik sovremennoj klinicheskoj mediciny. – 2016. – Vol. 2. – P.29-35.
Sakhipova Gulnara Adyevna (2016). Bronchopulmonary dysplasia in children. Baikal Medical Journal, 145 (6), 5-9.
Pavlinova E.B. Bronchopulmonary dysplasia: state of the art // Omskij Nauchnyj Vestnik. – 2011. – №4. – P.20-22.
Panchenko A.S., Gaimolenko I.N., Tikhonenko O.A., Ignatieva A.B. Bronchopulmonary dysplasia: causes of forming and morphology of pulmonary tissue // Sibirskij Medicinskij Zurnal (Irkutsk). – 2013. – Vol. 117. №2. – P.61-64.
Tatochenko V.K. Vaccination of preterm and LBW infants. // Pediatricheskaja farmakologija. – 2013. – Vol. 10. №4. – P.30-36.
Allen J., Zwerdling R., Ehrenkranz R., et al. American Thoracic Society. Statement on the care of the child with chronic lung disease of infancy and childhood // Am. J. Respir. Crit. Care Med. – 2003. – Vol. 168. – P.356-396.
