THE ROLE AND SIGNIFICANCE OF CHEMOTHERAPY IN MEDICINE
Abstract
Relevance. According to the latest statistical data from the Global Cancer Observatory (GLOBOCAN), in 2020, 19,292,789 new cases of malignant neoplasms and 9,958,133 deaths were registered worldwide. Prognostic calculations indicate that within the next five years, the total number of newly diagnosed cancer cases will reach 50,550,287, which confirms the extreme importance of oncological pathology as one of the most serious global health problems and also demonstrates the increasing dynamics of its spread.
Downloads
References
Hanahan D. Hallmarks of Cancer: New Dimensions // Cancer Discov. – 2022. – V. 12. – Р. 31–46. 2.
Kerk S., Papagiannakopoulos T., Shah Y., Lyssiotis C. Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment // Nat Rev Cancer. – 2021.
McCleary N.J., Benson A.B., 3rd, Dienstmann R. Personalizing Adjuvant Therapy for Stage II/III Colorectal Cancer // Am Soc Clin Oncol Educ Book. – 2017. – Vol. 37. – Р. 232–245.
Pavlova N., Thompson C. The Emerging Hallmarks of Cancer Metabolism // Cell Metab. – 2016. – V. 23. – Р. 27–47
Ponde N.F., Zardavas D., Piccart M. Progress in adjuvant systemic therapy for breast cancer // Nat Rev Clin Oncol. – 2019. – T. 16, № 1. – C. 27–44.
Stine Z., Schug Z., Salvino J., Dang C. Targeting cancer metabolism in the era of precision oncology // Nat Rev Drug Discov. – 2021.
Xu G., Wang H., Li X., Huang R., Luo L. Recent progress on targeting ferroptosis for cancer therapy // Biochem Pharmacol. – 2021. – Р. 114584.
Zhu H. Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations // Signal Transduct Target Ther. – 2022. – V. 7. – Р. 11.