HISTOMORPHOLOGICAL AND CLINICAL EFFICACY OF THIOTRIAZOLINE IN THE TREATMENT OF MULTIDRUG-RESISTANT PULMONARY TUBERCULOSIS: A RANDOMIZED CLINICAL-PATHOLOGICAL STUDY

Abstract

The aim of this randomized clinical and morphological study was to determine the efficacy of thiotriazoline as a pathogenetic component in the combination therapy of multidrug-resistant pulmonary tuberculosis (MDR-TB). The study included 142 patients with confirmed MDR-TB, divided into the main (n=81) and control (n=61) groups. The main group, along with standard chemotherapy, received a course of thiotriazoline . Clinical, laboratory and morphometric parameters were assessed before and after treatment. Histological analysis of lung tissue was performed in 52 patients. The results showed a significant decrease in the severity of caseous necrosis, alveolar septa thickness, fibrosis density and inflammatory infiltration in patients receiving thiotriazoline . Higher rates of bacteriological conversion, cavity closure and remission were also noted. The drug demonstrated a hepatoprotective effect and good tolerability. The data obtained indicate a significant morphologically confirmed pathogenetic effect of thiotriazoline and justify its inclusion in MDR-TB treatment protocols.