HUTCHINSON-GILFORD PROGEROID SYNDROME

Abstract

Hutchinson-Gilford progeria syndrome is an extremely rare, autosomal dominant syndrome that involves premature aging, generally leading to death at approximately 13 years of age due to myocardial infarction or stroke. The genetic basis of most cases of this syndrome is connected with LMNA gene, more specifically with lamin A. There have been some potential therapeutic approaches, including farnesyltransferase inhibitors (FTIs) and gene therapy, that have shown promise in addressing the underlying causes of Hutchinson-Gilford Progeria Syndrome (HGPS). In this review, we discuss the genetic mechanisms underlying the development of this syndrome, its genetic characteristics, and potential therapeutic approaches.