COMPARATIVE CHARACTERISTICS OF MORPHOFUNCTIONAL CHANGES IN THE THYROID GLAND IN EXPERIMENTAL RHEUMATOID ARTHRITIS

• Urakov Jamshid Rustamovich

  Department of Rehabilitation and Sports Medicine Bukhara State Medical Institute

  Author

Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic inflammation, persistent synovitis, and the formation of autoantibodies (especially against citrullinated peptides and rheumatoid factors) (1). With repeated episodes of joint inflammation, the normal structure of the joint is destroyed, ultimately leading to decreased mobility and increased disability (2). In addition, many patients with RA experience extra-articular clinical symptoms (3). Recently, a meta-analysis (4) estimated the global prevalence of RA to be approximately 0.46% over the past 40 years. Moreover, RA has been found to be potentially associated with various autoimmune diseases, including thyroid dysfunction. Thyroid dysfunction mainly includes hyperthyroidism, hypothyroidism, subclinical hyperthyroidism and subclinical hypothyroidism.

Scott D.L., Wolf F., Huizinga T.W. Rheumatoid arthritis. Lancet (2010) 376(9746):1094–108. doi: 10.1016/S0140-6736(10)60826-4

Li Q, Laumonier Y, Syrovets T , Simmet T. Yeast two-hybrid screen for proteins interacting with the plasmin receptor subunit: C-terminal fragment of annexin A 2 . Acta Pharmacol Sin (2011) 32(11):1411–8. doi :10.1038/ aps.2011.121 [ PMC free article ]

Ozcan M., Karakus M.F., Gunduz O.H., Tuncel U., Sahin H. Hearing loss and middle ear damage in rheumatoid arthritis. Rheumatol Int (2002) 22(1):16–9. doi : 10.1007 / s00296-002-0185 -z

Almutairi K, Nossaint J, Prien D, Kin H, Inderjit K. Global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int (2021) 41(5):863–77. doi: 10.1007/ s 00296-020-04731-0

Nazari K, Hussain N, Ojo RO, Anwar S, Kadooray F, Hafizyar F, et al . Prevalence of thyroid dysfunction in newly diagnosed patients with rheumatoid arthritis. Kureus. (2021) 13(9): e 18204. doi: 10.7759/ cureus .18204

Collins J. , Gough S. Autoimmunity in thyroid diseases. Eur J Nucl Med Mol Imaging (2002) 29 Suppl 2: S417–24. doi : 10.1007/s00259-002-0848-8

Conigliaro P, D'Antonio A, Pinto S, Chimenti MS, Triggianese P, Rotondi M, et al .: Autoimmune thyroid disease and rheumatoid arthritis: a bidirectional interaction. Autoimmune ed. (2020) 19(6):102529. doi :10.1016/ j . autrev.2020.102529

Sapin R., Schlinger J.L. Determination of thyroxine (T 4 ) and triiodothyronine (T3): methods and significance in assessing thyroid function. Ann Biol Klin ( Paris ) (2003) 61(4):411–20.

Chucker L., Razvi S., Bensenor I.M., Azizi F., Pierce E.N., Peters R.P. Hypothyroidism . Nat Rev Dis Primers (2022) 8(1):31. doi : 10.1038/s41572-022-00364-8

• PDF