HUMAN GENOME EDITING: ETHICAL CHALLENGES AND BIOMEDICAL APPLICATIONS
Keywords:
genome editing, CRISPR-Cas9, ethics, biomedical applications, genetic modification, human enhancement.Abstract
Human genome editing represents one of the most revolutionary advances in modern biotechnology. The ability to precisely modify the human genome through techniques such as CRISPR-Cas9 has created vast opportunities for preventing genetic diseases, enhancing therapeutic interventions, and improving human health. However, these scientific breakthroughs also raise serious ethical, legal, and social concerns. This paper explores the biomedical applications of human genome editing and critically evaluates the ethical challenges associated with its use, focusing on the balance between innovation and moral responsibility in the context of human dignity and bioethics.
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References
Doudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096.
National Academies of Sciences, Engineering, and Medicine. (2017). Human Genome Editing: Science, Ethics, and Governance. Washington, DC: National Academies Press.
World Health Organization (WHO). (2021). Human Genome Editing: Recommendations. Geneva.
Baylis, F. (2019). Altered Inheritance: CRISPR and the Ethics of Human Genome Editing. Harvard University Press.
Jasanoff, S., Hurlbut, J. B., & Saha, K. (2015). CRISPR Democracy: Gene Editing and the Need for Inclusive Deliberation. Issues in Science and Technology, 32(1), 25–32.
Ishii, T. (2017). Germline genome-editing research and its socioethical implications. Trends in Molecular Medicine, 23(12), 999–1010.
