COMPARATIVE MORPHOMETRIC CHARACTERISTICS OF THE LIVER DURING PREGNANCY IN EXPERIMENTAL ACUTE RENAL FAILURE

Authors

  • Rakhmonkulova N G Bukhara State Medical Institute named after Abu Ali Ibn Sino, Bukhara, Uzbekistan E-mail: raxmonqulova.nargiza@bsmi.uz Author

Keywords:

chronic renal failure, pregnancy, liver morphometry, hepatocyte, Kupffer cells.

Abstract

Acute kidney disease (AKD) during pregnancy remains a significant medical and social problem, strongly influencing the morphology and function of the liver. This study aimed to evaluate the morphometric and histological changes in the liver of pregnant white rats with experimentally induced chronic renal failure. A total of   60 seven-month-old rats were included in the experimental series. Histological analysis revealed marked alterations in hepatic architecture, including vacuolization of hepatocyte cytoplasm, deformation of the central vein wall, sinusoidal dilation, and increased Kupffer cell activity. These findings provide new insights into the mechanisms underlying hepatic dysfunction in pregnancy complicated by AKD and may contribute to improving early diagnosis and preventive strategies.

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Published

2025-10-11

Issue

Vol. 5 No. 50 (2025): MODELS AND METHODS FOR INCREASING THE EFFICIENCY OF INNOVATIVE RESEARCH

Section

Articles