EKSPERIMENTAL TADQIQOTLARDA GIPOKSIYA-INDUKSIYALANGAN FAKTOR (HIF-1Α) NING TOKSIK GEPATIT RIVOJLANISHIGA TA’SIRINI O’RGANISH.
Abstract
Ushbu ish geliotrin bilan toksik zaxarlanish natijasida rivojlanadigan toksik gepatitning patogenezida gipoksiya-induksiyalangan faktor 1 (HIF-1α) ning o’rnini eksperimental tarzda o’rganishga bag’ishlangan. Geliotrin — bu gepatit uchun juda xavfli bo’lgan pyrolizidin alkaloidi. Tadqiqot HIF-1α darajasining o’zgarishini, ya’ni jigarda kislorod yetishmasligini aniqlash uchun potentsial marker sifatida uning rolini va toksik gepatit rivojlanishidagi ishtirokini o’rganishga qaratilgan [4].
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References
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