ROLE OF THIAMIN DEFICIENCY IN THE HEART FAILURE
Keywords:
Thiamine deficiency (TD), heart failure (HF), adenosine triphosphate (ATP), glycolysis, cardiovascular system, adenosine, beriberi, cardiomyocyte.Abstract
Thiamine is a water soluble B1 vitamin available in cereal grains, egg, nuts and meat products. Thiamin is a required coenzyme in the energy-producing reactions that fuel myocardial contraction. So, thiamin deficiency may contribute to myocardial weakness by limiting the energy available for contraction. Studies have reported a wide range in the prevalence of thiamin deficiency in patients with heart failure (3–91 %). The impact of thiamin supplementation in patients with heart failure is inconclusive. Because, studies conducted to date are limited by their small sample size, indirect methods of assessing thiamin concentration, methodological inconsistencies, use of impractical means of thiamin supplementation, a focus on hospitalized patients. This article illustrates the role of thiamine in the body and the importance of thiamine deficiency in heart failure.
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References
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