THE ASSOCIATION BETWEEN BACTERIAL COLONIZATION AND INTERLEUKIN-8 (IL-8) LEVELS IN COPD EXACERBATIONS

Authors

  • Atazhanova N.M., Khorezm Branch of the Republican Scientific Center for Emergency Medical Aid (RSCEMA) Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan Author
  • Kamalov Z.S. Khorezm Branch of the Republican Scientific Center for Emergency Medical Aid (RSCEMA) Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan Author

Keywords:

In COPD, an inflammatory lung disease, elevated levels of interleukins underline their potential role in disease pathogenesis. Moreover, bacterial infections in patients with COPD are associated with increased levels of pro-inflammatory cytokines, particularly interleukin-8 (IL-8), which plays a crucial role in neutrophil recruitment to infection sites and the amplification of the inflammatory response.

Abstract

In recent years, interleukins have emerged as significant targets in research, diagnostics, and therapeutic strategies. Interleukins are a group of cytokines produced by immune cells to regulate inflammation. They interact with other immune components to elicit an effective inflammatory response. Consequently, interleukins can either stimulate or suppress inflammation, depending on the context and the timing of their production. Dysregulation of interleukin activity in the lungs is implicated in the chronic inflammation characteristic of chronic obstructive pulmonary disease (COPD). 

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Published

2024-11-01

Issue

Vol. 2 No. 15 (2024): PROSPECTS AND MAIN TRENDS IN MODERN SCIENCE

Section

Articles