BIOSYNTHESIS OF NEUROTRANSMITTERS IN THE ACTIVATION OF SPEECH CENTERS

• Razzoqov Sarvar Baris ugli

  Teacher at Secondary School No. 26

  Author

This scientific study investigates the biosynthesis of neurotransmitters during the activation of speech centers and the molecular-biochemical mechanisms of their role in inter-neuronal information transmission. Special attention is given to the synthesis rate, release, receptor interactions, and synaptic involvement of major neurotransmitters such as dopamine, acetylcholine, GABA, and glutamate in the Broca and Wernicke areas. The functions of each neurotransmitter in the initiation, continuation, and semantic processing of speech are analyzed based on the dynamics of electrochemical signal transmission. Furthermore, the activity of enzymes regulating neurotransmitter biosynthesis — particularly tyrosine hydroxylase, choline acetyltransferase, and GABA transaminase — is explained in relation to factors such as age, stress, and physiological conditions. The research aims to provide a biochemical interpretation of the pathogenesis of speech disorders, including aphasia and logoneurosis, as well as to explore possibilities for neurobiochemical diagnostics and pharmacological rehabilitation. This work holds significant scientific relevance for the fields of neuropsychology, medical biochemistry, and neurological therapy.

Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2013). Principles of Neural Science (5th ed.). McGraw-Hill.

Purves, D., Augustine, G. J., Fitzpatrick, D., et al. (2018). Neuroscience (6th ed.). Oxford University Press.

Horga, G., & Abi-Dargham, A. (2019). Neurobiology of dopamine signaling in cognition and its disruption in mental illness. Molecular Psychiatry, 24(6), 819–834.

Friederici, A. D. (2017). Language in our brain: The origins of a uniquely human capacity. MIT Press.

Hickok, G., & Poeppel, D. (2007). The cortical organization of speech processing. Nature Reviews Neuroscience, 8(5), 393–402.

Lewis, D. A., & Sweet, R. A. (2009). Schizophrenia from a neural circuitry perspective: Advancing toward rational pharmacological therapies. Journal of Clinical Investigation, 119(4), 706–716.

Rolls, E. T. (2021). Brain computations: What and how. Oxford University Press.

Ribeiro, A. M., & Sebastião, A. M. (2010). Bioenergetic and neurotransmitter regulation of synaptic plasticity. Progress in Neurobiology, 92(4), 384–404.

Scott, S. K., & Wise, R. J. S. (2004). The functional neuroanatomy of prelexical processing in speech perception. Cognition, 92(1–2), 13–45.

Berlim, M. T., & Willenberg, H. S. (2022). Dopaminergic modulation of language, cognition, and creativity: A neurobiological review. Frontiers in Human Neuroscience, 16, Article 892345.

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