ALGORITHM FOR EARLY DIAGNOSIS AND ROUTING OF PATIENTS WITH HPV-ASSOCIATED OROPHARYNGEAL CANCER FOR PRIMARY CARE PHYSICIANS.

• Kurbanov Khurshid Abduburkhanovich

  Author

• Mamedova Guzal Bakirovna

  Author

• Alimov Ijod Rustamjonovich

  Author

 Modern oncology has faced an unprecedented epidemiological shift in the structure of head and neck cancer incidence. While at the end of the 20th century, oropharyngeal squamous cell carcinoma was primarily associated with tobacco smoking and alcohol consumption, over the past two decades, the dominant etiological cause has become high-risk human papillomavirus (HPV, predominantly type 16) [1, 2]. The proportion of HPV-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) in developed countries reaches 60-80%, showing a steady increase [3]. In Central Asian countries, including Uzbekistan, an increase in the number of HPV-OPSCC cases is also noted, which requires a revision of national diagnostic strategies [4].

Ang K.K. et al. N Engl J Med. 2010;363(1):24-35.

Chow L.Q.M. N Engl J Med. 2020;382(1):60-72.

Marur S. et al. Lancet Oncol. 2010;11(8):781-9.

Романов И.С. и соавт. Пробл. стандартизации в здрав. 2022;(5-6):78-85.

Fakhry C. et al. J Natl Cancer Inst. 2008;100(4):261-9.

Мельников А.В. и соавт. Онкология. 2021;10(3):45-52.

Пачес А.И. и соавт. Опухоли головы и шеи. М.: Практическая медицина; 2019.

Семёнов Ф.В., Абдуллаев Т.А. Организация здравоохранения. 2020;(4):12-20.

NCCN Guidelines. Head and Neck Cancers. Version 3.2023.

Национальная программа по борьбе с онкологическими заболеваниями в Узбекистане на 2023-2027 гг. Ташкент; 2022.

WHO Classification of Tumours. Head and Neck Tumours. 5th ed. IARC; 2022.

Оганесян С.С., Ким И.А. Практ. онкология. 2019;20(1):9-18.

Клинические рекомендации «Плоскоклеточный рак ротоглотки». Минздрав России, 2023.

Семёнов Ф.В. и соавт. Вопр. орг. инф. здрав. 2021;(2):34-41.

Gupta A. et al. Cancer. 2021;127(18):3394-3404.

• PDF