GIPERTERMIYA BILAN BOG‘LIQ IMMUNITET TIZIMINING MODULYATSIYASI HAQIDA.
Keywords:
gipertermiya, issiqlik zarbasi oqsillari, dendritik hujayralar, immunogen o'simta hujayralarining o'limi, abskopal ta'sirlar.Abstract
Gipertermiya (HT) radioterapiya (RT) va kimyoterapiya (KT) uchun kuchli sensibilizator bo'lib, tug'ma va adaptiv immunitet tizimining hujayralarini bevosita yoki bilvosita modulyatsiya qilishi isbotlangan. Biz ushbu maqolada o'smaga qarshi immunitetni HT tomonidan qanday qo'zg'atilishi mumkinligiga e'tibor qaratamiz. Ba'zi in vitro tahlillaridan farqli o'laroq, in vivo tekshiruvlar tabiiy qotil hujayralar va granulotsitlar kabi fagotsitlar HT tomonidan o'simtaga qarshi bevosita faollashtirilganligini ko'rsatdi. Issiqliq dendritik hujayralarni (DC) ham faollashtirganligi sababli, HT, masalan, nekrotik o'simta hujayralaridan olingan o'simta antijenini DK tomonidan qabul qilish uchun ajratish uchun keyingi o'lim stimullari (RT, KT yoki immunoterapiya) bilan birlashtirilishi kerak. Immunogen o'simta hujayralarini induktsiya qilish va boshqa davolash usullari bilan birgalikda HT tomonidan o'simta hujayralarini to'g'ridan-to'g'ri o'ldirish o'simtaga qarshi immunitetni faollashtirishga yordam beradi. HT ning immunitet hujayralariga foydali bo'lmagan ta'siri asosan vaqtincha cheklanganligini ko'rsatadigan tadqiqotlar taqdim etiladi.
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