THE USE OF DEPOLARIZING MUSCLE RELAXANTS IN ANESTHESIA: STRENGTHS AND WEAKNESSES
Keywords:
succinylcholine, depolarizing muscle relaxants, rapid sequence induction, anesthesia, neuromuscular blockadeAbstract
Depolarizing muscle relaxants, particularly succinylcholine, are widely utilized in modern anesthesia for facilitating tracheal intubation and optimizing surgical conditions. While their rapid onset and short duration of action make them advantageous in certain clinical scenarios, these agents are not without limitations. This article explores the pharmacological properties, clinical applications, advantages, and drawbacks of depolarizing muscle relaxants in anesthesia practice.
Downloads
References
Miller, R. D., Eriksson, L. I., Fleisher, L. A., Wiener-Kronish, J. P., & Cohen, N. H. (2014). Miller’s Anesthesia (8th ed.). Elsevier.
Butterworth, J. F., Mackey, D. C., & Wasnick, J. D. (2018). Morgan & Mikhail’s Clinical Anesthesiology (6th ed.). McGraw Hill.
Martyn, J. A., Richtsfeld, M., & Su, J. X. (2005). “Clinical pharmacology of succinylcholine and its use in anesthesiology.” Anesthesia & Analgesia, 101(6), 1448-1455.
Fuchs-Buder, T., Claudius, C., Skovgaard, L. T., & Eriksson, L. I. (2009). “Second International Consensus Conference on Muscle Relaxants: Succinylcholine revisited.” Anesthesia & Analgesia, 108(6), 1586-1596.
Heier, T., & Caldwell, J. E. (2006). “Rapid tracheal intubation: A review of the use of succinylcholine and its alternatives.” Journal of Clinical Anesthesia, 18(7), 551-563.
Hopkins, P. M. (2000). “Malignant hyperthermia: Advances in clinical management and diagnosis.” British Journal of Anaesthesia, 85(1), 118-128.
Schreiber, J. U., Lysakowski, C., Fuchs-Buder, T., & Tramèr, M. R. (2005). “Prevention of succinylcholine-induced fasciculation and myalgia: A meta-analysis of randomized trials.” Anesthesiology, 103(4), 877-884.
Naguib, M., Lien, C. A., Kopman, A. F., & Brull, S. J. (2017). “Pharmacology of muscle relaxants and their antagonists.” In Miller’s Anesthesia (8th ed.), Elsevier, 937-969.
Sugammadex: A Selective Relaxant Binding Agent for Reversal of Neuromuscular Block. (2020). Journal of Clinical Anesthesia, 64, 109832.
Bevan, D. R., Donati, F., & Kopman, A. F. (1992). “Reevaluation of the dose-response relationship of succinylcholine in humans.” Anesthesiology, 76(1), 47-55.
