CLINICAL COURSE RHEUMATOID ARTHRITIS DEPENDING ON BLOOD LEVELS OF ADAMTS7

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive inflammation of the synovial membrane and joint destruction. In recent years, biomarkers reflecting the pathogenetic mechanisms of the disease and the prognosis of its course have been actively studied. The ADAMTS7 enzyme (a disintegrin and metalloproteinase with thrombospondin motifs 7) is of particular interest, which participates in the remodeling of the extracellular matrix and the development of erosive joint changes. Elevated levels of ADAMTS7 may be associated with a more aggressive course of the disease.