KICHIK MOLEKULA INGIBITORLARI
Abstract
Dimetiloksalilglitsin va prolil gidroksilaza ingibitori kabi bir nechta kichik molekulalar HIF-1 ni faollashtiradi. Gidroksilaza faolligi ma'lum hududlarning mutatsiyasi yoki hujayraga kobalt ionlarini qo'shish orqali ingibitor qilinishi mumkin, ular bog'lanish joylari uchun temir bilan raqobatlashadi. Ba'zi prolil gidroksilazalar in vitroda adriamitsin tomonidan tanlab ingibitor qilinishi mumkin.
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References
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