LIPIDLARNING OKSIDLANISH JARAYONI
Abstract
Lipid peroksidlanishi – bu oksidlovchilar, masalan, erkin radikallar yoki no-radikal zarrachalar, uglerod-uglerod qo‘sh bog‘larini o‘z ichiga olgan lipidlarga, ayniqsa ko‘p to‘yinmagan yog‘ kislotalariga (PUFA) hujum qiladigan jarayondir. Bu jarayonda ugleroddan vodorod ajralib chiqib, kislorod qo‘shiladi va natijada peroksil radikallar hamda gidroperoksidlar hosil bo‘ladi. Glykolipidlar, fosfolipidlar (PL) va xolesterin (Ch) ham ushbu jarayonga ta’sir qiluvchi moddalar bo‘lib, potensial xavfli peroksidativ modifikatsiyalarga olib kelishi mumkin. Shuningdek, lipidlar lipoksigenazalar, siklooksigenazalar va sitoxrom P450 kabi fermentlar ishtirokida oksidlanishi mumkin.
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References
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