MITOXONDRIAL DISFUNKTSIYA: BIOKIMYOVIY ASOSLARI VA KLINIK AHAMIYATI
Keywords:
Mitoxondrial disfunktsiya; Bioenergetika; Elektron transport zanjiri; Reaktiv kislorod turlari (ROS); mtDNK mutatsiyasi; Mitofagiya; Oksidlovchi stress; ATP sintezi; Mitoxondrial biogenez; Molekulyar diagnostika; Antioksidant terapiya.Abstract
Ushbu maqolada mitoxondrial disfunktsiyaning biokimyoviy asoslari, uning hujayra va organizm darajasidagi ta’sirlari, diagnostika metodlari hamda zamonaviy davolash usullari batafsil tahlil qilinadi. Mitoxondriya funktsiyasining buzilishi energetik muvozanatning buzilishiga, oksidlovchi stressning oshishiga va hujayra apoptozining faollashishiga olib keladi, bu esa ko‘plab kasalliklarning rivojlanishida muhim rol o‘ynaydi. Diagnostika usullari orasida ATP sintezi, elektron transport zanjiri fermentlarining faolligi, mtDNK mutatsiyalari va mitoxondriya morfologiyasini baholash texnologiyalari mavjud. Davolash strategiyalari esa metabolik qo‘shimchalar, antioksidantlar, genetik terapiyalar va mitoxondrial biogenezni rag‘batlantiruvchi yondashuvlarni o‘z ichiga oladi. Maqola mitoxondrial disfunktsiyani chuqur tushunish va uning samarali davolash imkoniyatlarini kengaytirishga qaratilgan zamonaviy ilmiy tadqiqotlarni yoritadi.
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