STUDY OF THE BIOLOGICAL ACTIVITY OF COMPLEX COMPOUNDS OF NI (II), CO (II) AND ZN (II) METALS WITH VITAMINS AND AMINO ACIDS USING THE MOLECULAR DOCKING METHOD

Authors

  • Buvrayev Erali Ravshanovich Author
  • Trobov Khamza Tursunovich Author
  • Gaybullaev Shukhrat Sharof ogli Author

Keywords:

Protein Data Bank, MurA enzymes, inhibition potential, Escherichia coli, Staphylococcus aureus, Strain, Protein.

Abstract

The growing global problem of antibiotic resistance poses serious challenges in the treatment of infectious diseases and necessitates the development of new antibacterial agents. Against the background of the ineffectiveness of existing antibiotics, the identification of new targets that play an important role in the vital processes of bacteria and the creation of effective inhibitors against them are of urgent importance.

Downloads

Download data is not yet available.

References

Breyer, A., & Breyer, R. M. (2019). Antibiotic resistance: a global crisis. Advances in pharmacology, 86, 341-372.

Mengin-Lecreulx, D., & van Heijenoort, J. (1996). MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) and the first committed step of peptidoglycan synthesis: a promising target for novel antibacterial agents. FEMS microbiology reviews, 18(3), 167-184.

Sadler, P. J. (2008). Medicinal inorganic chemistry. Coordination Chemistry Reviews, 252(21-22), 2105-2120.

পানি, S. K., & পানি, P. (2020). Organometallic compounds as antimicrobial agents: A review. Journal of Organometallic Chemistry, 923, 121422.

Yakhontova, L. D., & Zavgorodnyaya, A. N. (2018). Biostimulators in agriculture: classification and application. * достижения науки и техники АПК*, (12), 5-8.

Kitchen, D. B., Jazayeri, J. A., Colby, D. W., & Jorgensen, W. L. (2004). Docking and scoring in drug discovery: methods and applications. Nature Reviews Drug Discovery, 3(11), 935-949.

Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: automated docking of flexible ligands to macromolecules. Journal of computational chemistry, 30(16), 2785-2791.

Downloads

Published

2025-04-25