HCT116 YO’G’ON ICHAK SARATONI HUJAYRA LINIYASIDA HAJMGA BOG’LIQ ANION KANALI (HBAK) MUTATSIYALARINING BIOINFORMATIK TAHLILI VA UNING FARMAKOLOGIK XUSUSIYATLARI
Abstract
Yo’g’on ichak saratoni (YKSR) global miqyosda muhim sog’liq muammosi hisoblanadi. HCT116 – YKSRni o’rganishda keng qo’llaniladigan hujayra liniyasi. Hajmga bog’liq anion kanali (HBAK) hujayra hajmini tartibga solishda va saraton hujayralari faoliyatida muhim rol o’ynaydi[1].
Ushbu tadqiqotning maqsadi HCT116 hujayra liniyasida HBAK (Cl- anion kanali) bilan bog’liq genlardagi mutatsiyalarni bioinformatik tahlil qilish, shuningdek, uning farmakologik xususiyatlarini o’rganish orqali saraton biologiyasiga oid yangi ma’lumotlarni aniqlashdan iborat.
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References
LRRC8/VRAC volume-regulated anion channels are crucial for hearing Received for publication, January 22, 2024, and in revised form, May 9, 2024 Published, Papers in Press, June 4, 2024, https://doi.org/10.1016/j.jbc.2024.107436 Deborah A. Knecht1,2
