THE ROLE OF ADAMTS7 IN THE ACTIVATION AND PROGRESSION OF REACTIVE ARTHRITIS

Authors

  • M.A. Artikbayev 1 MD, "IMPULS BSR" Impuls Medical Institute, Namangan Author
  • Akhmedov Kh.S 2Tashkent State Medical University2 Author
  • Khalmetova F.I 2Tashkent State Medical University2 Author

Keywords:

A key mechanism in disease pathogenesis involves the activation of inflammatory cascades mediated by cytokines such as TNF-α and IL-17A, as well as enzymatic systems that damage cartilage and periarticular structures. ADAMTS7, a metalloproteinase, contributes to extracellular matrix degradation and has been associated with joint destruction in various rheumatic diseases.

Abstract

Reactive arthritis (ReA) is a post-infectious inflammatory joint disease that may present as either a mild, self-limiting condition or progress to chronic erosive arthritis. 

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Published

2025-10-01

Issue

Vol. 4 No. 45 (2025): FORMATION OF PSYCHOLOGY AND PEDAGOGY AS INTERDISCIPLINARY SCIENCES

Section

Articles