ANTIHISTAMINES AS PREVENTIVE AGENTS FOR BRONCHOSPASM AND LARYNGOSPASM: EXPANDING THE SCOPE OF PROPHYLACTIC THERAPY

Authors

  • Umidbek Dusmatov Alisher ugli Author

Keywords:

Bronchospasm and laryngospasm are two of the most common causes of airway compromise, presenting significant morbidity and mortality risks. Inflammatory mediators such as histamine,

Abstract

The prophylactic use of antihistamines in preventing bronchospasm and laryngospasm has garnered attention due to their ability to block histamine-mediated airway responses. Histamine’s role in bronchial and laryngeal constriction is pivotal in conditions such as asthma, anaphylaxis, and perioperative airway complications. This review explores antihistamines’ pharmacological properties, mechanisms of action, and their role as standalone or adjunctive agents in clinical settings. Evidence from trials and real-world applications supports their integration into treatment protocols, though further research is warranted to optimize their utility in diverse patient populations.

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References

Lieberman, P., et al. “Management of Anaphylaxis: Antihistamines in Practice.” Allergy & Clinical Immunology, 2023.

Simons, F. E. “H1-Antihistamines and Airway Diseases.” NEJM, 2021.

Tohda, Y., et al. “Histamine in Asthma Pathophysiology: Role of H1 and H2 Blockade.” Pulmonary Pharmacology & Therapeutics, 2022.

Church, M. K., Maurer, M. “Antihistamines: Clinical Pharmacology and Use in Allergic Disorders.” Pharmacology Reviews, 2020.

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Published

2024-12-26