AVLODDAN-AVLODGA O'TUVCHI EPIGENETIK O'ZGARISHLAR: ONA HOMILADORLIK DAVRIDAGI STRESSNING FARZAND SALOMATLIGIGA TA'SIRI
Keywords:
epigenetika, prenatal stress, DNK metilatsiyasi, avloddan-avlodga o‘tuvchi o‘zgarishlar, NR3C1 geni.Abstract
Ushbu maqolada ona homiladorlik davrida kechirgan stressning farzand salomatligiga epigenetik mexanizmlar orqali ko‘rsatadigan ta’siri yoritilgan. Ilmiy adabiyotlarda prenatal stress DNK metilatsiyasi, histon modifikatsiyalari va mikroRNK ekspressiyasi kabi epigenetik o‘zgarishlarga sabab bo‘lishi qayd etilgan. Ayniqsa, stress gormoni bilan bog‘liq NR3C1 va FKBP5 genlari faoliyatidagi o‘zgarishlar farzandlarda stressga nisbatan yuqori sezuvchanlik, ruhiy-psixologik buzilishlar hamda somatik kasalliklarga moyillikni kuchaytirishi mumkinligi ta’kidlanadi. Ushbu maqolada mavjud tadqiqotlar tahlil qilinib, prenatal davrdagi stressning avloddan-avlodga o‘tuvchi epigenetik ta’sirlari ko‘rib chiqildi.
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