MITOXONDRIYAL KASALLIKLAR VA GIPOENERGETIK HOLATLAR
Keywords:
mitoxondriyal patologiya, gipoenergetik holat, hujayra energetikasiAbstract
Mitoxondriyalar hujayra ichidagi energiya almashinuvining markaziy bo‘g‘ini bo‘lib, ular tomonidan ishlab chiqariladigan adenozin trifosfat (ATP) barcha biologik jarayonlarning davom etishini ta’minlaydi. Mitoxondriyal kasalliklar mitoxondriyal yoki yadroviy genomdagi irsiy mutatsiyalar natijasida yuzaga kelib, oksidlovchi fosforillanish jarayonining izdan chiqishiga olib keladi. Natijada hujayralarda gipoenergetik holat shakllanib, energiyaga yuqori ehtiyoj sezuvchi to‘qima va a’zolarda funksional buzilishlar rivojlanadi. Ushbu maqolada mitoxondriyal kasalliklarning molekulyar-genetik asoslari, gipoenergetik holatlarning patofiziologik mexanizmlari hamda ularning klinik ahamiyati keng yoritilgan. Shuningdek, energiya tanqisligi bilan bog‘liq tizimli o‘zgarishlarning organizm homeostaziga ta’siri ilmiy nuqtai nazardan tahlil qilingan.
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